Precision cell signaling activities of reactive electrophilic species (RES) are arguably among the most poorly‐understood means to transmit biological messages. Latest research implicates native RES to be a chemically‐distinct subset of endogenous redox signals that influence cell decision making through non‐enzyme‐assisted modifications of specific proteins. Yet, fundamental questions remain regarding the role of RES as bona fide second messengers. Here, we lay out three sets of criteria we feel need to be met for RES to be considered as true cellular (...) signals that directly mediate information transfer by modifying “first‐responding” sensor proteins. We critically assess the available evidence and define the extent to which each criterion has been fulfilled. Finally, we offer some ideas on the future trajectories of the electrophile signaling field taking inspiration from work that has been done to understand canonical signaling mediators. (shrink)

It is generally agreed that dispositions cannot be analyzed in terms of simple subjunctive conditionals (because of what are called “masked dispositions” and “finkish dispositions”). I here defend a qualified subjunctive account of dispositions according to which an object is disposed to Φ when conditions C obtain if and only if, if conditions C were to obtain, then the object would Φ ceteris paribus . I argue that this account does not fall prey to the objections that have been raised (...) in the literature. (shrink)

Daniel and Frances Howard-Snyder suggest that it is possible for an omnipotent being, Jove, to create randomly a world from a continuum of ever more perfect possible worlds. They then go on to argue that Jove could be characterized as morally unsurpassable despite creating a surpassable world. I raise a number of problems for the view that Jove could be characterized as morally unsurpassable when he creates (randomly or not) a surpassable world.

Given that an analysis of disposition ascription cannot be made in terms of a simple subjunctive conditional, we present a multiply qualified conditional analysis that places disposition ascription within an implicit fundamental causal conceptual typography within which a disposition ascription is embedded, framed, and understood. By placing the multiply qualified analysis within an implicit causal matrix involving a focal cause, pathway of influence, mechanism of action, contributing/partial cause, mediator, extrinsic moderator,, intrinsic moderator, and manifestation, we show how this analysis evades (...) counterexamples and arguments raised against the simple conditional analysis. We then indicate how the causal conceptual landscape provides a roadmap for unpacking and explicating parameters of the ceteris paribus qualifier to acquit the analysis of charges of being vacuous or irredeemably vague. (shrink)

Leibniz argued that God would not create a world unless it was the best possible world. I defend Leibniz’s argument. I then consider whether God could refrain from creating if there were no best possible world. I argue that God, on pain of contradiction, could not refrain from creating in such a situation. I conclude that either this is the best possible world or God is not our creator.

Fritz Allhoff has recently offered an extremely compelling challenge to the morality of human cloning. He argues that a biological phenomenon, that of telomere shortening, undermines the moral permissibility of human cloning. Telomere shortening is caused by cell replication, and appears to be one of the central reasons that cells and organisms age and die. Allhoff considers a thirty-year-old woman who wishes to create a genetic clone. He notes that the DNA from her cell that would be used to create (...) the clone would have shortened telomeres—as it would have gone through many generations of cell replication. As a result, the clone would begin its existence with shortened telomeres; the clone’s telomeres would be the same length as the woman’s telomeres at the time of cloning. The moral problem lies in the fact that because of shortened telomeres, the clone will senesce more rapidly as compared with noncloned organisms, and would have increased susceptibility to degenerative conditions and diseases. Allhoff then goes on to argue that earlier senescence and disease susceptibility constitute a moral ground for rejecting cloning because “the life of a clone would be worse than that of a non-clone”. This line of argument is rooted in Parfit’s The Same Number Quality Claim : “If in either of two outcomes the same number of people would ever live, it would be bad if those who live are worse off, or have a lower quality of life, than those who would have lived”. Applying Parfit’s Q principle to cases of cloning, it could be argued that parents ought to produce children that would be maximally well off, and since clones would be worse off than children produced “normally,” it follows that parents should avoid cloning. As Allhoff puts it, “obviously sexual reproduction would not transfer shortened telomeres to offspring so, all else being equal, sexual reproduction is better than cloning ”. For this sort of line to pack any moral punch, Q must be interpreted rather strongly. (shrink)

Daniel and Frances Howard-Snyder suggest that it is possible for an omnipotent being, Jove, to create randomly a world from a continuum of ever more perfect possible worlds. They then go on to argue that Jove could be characterized as morally unsurpassable despite creating a surpassable world. I raise a number of problems for the view that Jove could be characterized as morally unsurpassable when he creates (randomly or not) a surpassable world.

In defending the scientific legitimacy of ceteris paribus qualified causal generalizations, we situate and specify the reference of the ceteris paribus proviso within a fundamental causal framework consisting of causal agents, pathways of influence, mediators, moderators, and causal consequences. In so doing, we provide an explication of the reference and utility of the ceteris paribus proviso in terms of mediators and moderators as these constitute the range of factors that can impinge on the relation between cause and effect. We argue (...) that the conceptual causal roadmap embodied by the ceteris paribus qualification serves as a schematic template for the ongoing identification of causally relevant factors and plays an indispensable heuristic role in advancing scientific inquiry into causal relations. We then provide guidelines for differentiating between acceptable and unacceptable uses of ceteris paribus and describe how mediators and moderators conceptually encompassed by the ceteris paribus proviso can be employed in evaluating the meaning and acceptability of proposed ceteris paribus causal generalizations, as well serve as a guide to investigators in the process of designing studies to identify a causal agent, mediators, moderators, pathways of influence, and causal consequences. 2012 APA, all rights reserved). (shrink)

We consider and reject a variety of attempts to provide a ground for identifying and differentiating disembodied minds. Until such a ground is provided, we must withhold inclusion of disembodied minds from our picture of the world.

Abstract:The propositional attitude account of belief holds that belief involves a favorable mental attitude borne by an agent toward a proposition. On what the authors term the "Inner Assent" account of belief, such a mental attitude has been characterized in such terms as inner assent, inner affirmation, inner acceptance, or inner agreement. As such, the Inner Assent account can be seen as an effort to characterize the phenomenology of belief in terms of a phenomenology of inner assent or kindred notions. (...) Focusing on the notion of inner assent, counterexamples are presented to show that inner assent to a proposition is neither necessary nor sufficient to confer belief. The second part of the paper questions the ontological status of such purported attitudinal cognitive qualia. The authors argue that scenarios corresponding to assenting to p, affirming that p, accepting that p, agreeing that p, and so on are not identified and individuated by reference to proprietary coinciding attitudinal cognitive qualia. They include discussion of so-called phenomenal contrast cases where sensory phenomenal states had by two individuals are alike but differ in intentional content. In the case of belief, arguments against the Inner Assent account serve to preclude recourse to a phenomenology of inner assent and point to a significant disanalogy between reading a sentence and understanding it and reading a sentence that is believed to be true. (shrink)

Numerous examples have been offered that purportedly show that God cannot be omnipotent. I argue that a common response to such examples (i.e., that failure to do the impossible does not indicate a lack of power) does not preserve God’s omnipotence in the face of some of these examples. I consider another possible strategy for preserving God’s omnipotence in the face of these examples and find it wanting.

This chapter contains sections titled: How Does One Avoid Skepticism? The Experience Machine Contextualism My Take on Skepticism Notes.

The philosophy of the blues From B.B. King to Billie Holiday, Blues music not only sounds good, but has an almost universal appeal in its reflection of the trials and tribulations of everyday life. Its ability to powerfully touch on a range of social and emotional issues is philosophically inspiring, and here, a diverse range of thinkers and musicians offer illuminating essays that make important connections between the human condition and the Blues that will appeal to music lovers and philosophers (...) alike. (shrink)

Recent years have seen a problematic upward trend in disequilibrium in the international balance of payments. What accounts for this trend? Three hypotheses for the rise in disequilibrium are tested in this paper: greater fixedness of the world exchange rate regime causes greater disequilibrium; greater flexibility of the exchange rate regime causes greater disequilibrium; and a decline of United States economic hegemony causes greater disequilibrium. It is argued here that the problem was created by state choices, a lack of coordination (...) among states in the international system, and the absence of an international exchange rate regime. The evidence presented in this paper supports the idea that a stable international exchange rate regime is critical to secure a healthy world economy. (shrink)

_The philosophy of the blues_ From B.B. King to Billie Holiday, Blues music not only sounds good, but has an almost universal appeal in its reflection of the trials and tribulations of everyday life. Its ability to powerfully touch on a range of social and emotional issues is philosophically inspiring, and here, a diverse range of thinkers and musicians offer illuminating essays that make important connections between the human condition and the Blues that will appeal to music lovers and philosophers (...) alike. (shrink)

Retaliation against whistleblowers is a well-recognized problem, yet there is little explanation for why uninvolved peers choose to retaliate through ostracism. We conduct two experiments in which participants take the role of a peer third-party observer of theft and subsequent whistleblowing. We manipulate injunctive norms and descriptive norms. Both experiments support the core of our theoretical model, based on social intuitionist theory, such that moral judgments of the acts of wrongdoing and whistleblowing influence the perceived likeability of each actor and (...) ultimately influence intention to ostracize each actor and indicate more willingness to ostracize the whistleblower than the wrongdoer. When we vary norms for the wrongdoing in Experiment 1, we find that descriptive and injunctive norms indirectly influence intentions to ostracize both the wrongdoer and whistleblower. These relationships are serially mediated by the observers’ moral judgments of the act and likeability of the actor. When we vary norms for whistleblowing in Experiment 2, the injunctive norm manipulation affected moral judgment of the action of whistleblowing, and we do not observe any other significant effects of the norm manipulations on moral judgments of the actions of wrongdoing or whistleblowing. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The essays in this book, by a variety of leading Augustine scholars, examine not only Augustine's multifaceted philosophy and its relation to his epoch-making theology, but also his practice as a philosopher, as well as his relation to other philosophers both before and after him. Thus the collection shows that Augustine's philosophy remains an influence and a provocation in a wide variety of settings today.

Let N, O and S denote the set of nonnegative integers, the graph of the constant 0 function and the graph of the successor function respectively. For sets $P, Q, R \subseteq N^2$ operations of transposition, composition, and bracketing are defined as follows: $P^\cup = \{\langle x, y\rangle | \langle y, x\rangle \epsilon P\}, PQ = \{\langle x, z\rangle| \exists y\langle x, y\rangle \epsilon P & \langle y, z\rangle \epsilon Q\}$ , and [ P, Q, R] = ∪n ε M(PnQR (...) n). THEOREM. The class of recursively enumerable subsets of N2 is the smallest class of sets with O and S as members and closed under transposition, composition, and bracketing. This result is derived from a characterization by Julia Robinson of the class of general recursive functions of one variable in terms of function composition and "definition by general recursion." A key step in the proof is to show that if a function F is defined by general recursion from functions A, M, P and R then F = [ P∪, A∪ M, R]. The above definitions of the transposition, composition, and bracketing operations on subsets of N2 can be generalized to subsets of X2 for an arbitrary set X. In this abstract setting it is possible to show that the bracket operation can be defined in terms of K, L, transposition, composition, intersection, and reflexive transitive closure where K: X → X and L: X → X are functions for decoding pairs. (shrink)

Any theory of semantic cognition is also a theory of concepts. There are two ways to construe the models presented by Rogers & McClelland (R&M) in Semantic Cognition. If we construe the input and output representations as concepts, then the models capture knowledge acquisition within a stable set of concepts. If we construe the hidden-layer representations as concepts, the models provide a simulation of conceptual change.

In Enchanted Looms , Rodney Cotterill defends the hypothesisthat conscious sensory experience depends on motor response. Thepositive evidence for this hypothesis is inconclusive, andnegative evidence can be marshaled against it. I present analternative hypothesis according to which consciousness involvesintermediate level sensory processing, attention, and workingmemory. The circuitry of consciousness can be dissociated fromaction systems and may mark an evolutionary advance from a priorphylogenetic stage in which motor outputs and sensory inputswere more intimately bound.

This paper identifies a neglected manuscript, Viterbo, Centro Diocesano di Documentazione, Capitolare 51, as the extant archetype of the Libri Romani version of the glossary of Placidus. It first demonstrates that R is the parent of the three witnesses to the Libri Romani text used by editors, and it considers the implications of the neglected manuscript for future editions of the text. It then corroborates the importance of R by tracing its travels in humanistic and antiquarian circles in Italy in (...) the fifteenth and sixteenth centuries. This history provides a framework for future research on the textual transmission of the Libri Romani text of Placidus. (shrink)

This piece, included in the drift special issue of continent. , was created as one step in a thread of inquiry. While each of the contributions to drift stand on their own, the project was an attempt to follow a line of theoretical inquiry as it passed through time and the postal service(s) from October 2012 until May 2013. This issue hosts two threads: between space & place and between intention & attention . The editors recommend that to experience the (...) drifiting thought that attention be paid to the contributions as they entered into conversation one after another. This particular piece is from the BETWEEN SPACE & PLACE thread: April Vannini, Those Between the Common * Laura Dean & Jesse McClelland, Ballard: A Portrait of Placemaking * Amara Hark Weber, Crossroad * Isaac Linder & Berit Soli-Holt, The Call of the Wild: Terro(i)r Modulations * Ashley D. Hairston, Momma taught us to keep a clean house * Sean Smith, The Garage (Take One) * * * * Ballard: A Portrait of Placemaking from continent. on Vimeo . How do people perceive changing landscapes and lifestyles in our neighborhood? We were drawn to this question, perhaps like our interviewees, because we are interested in a certain mystique in Ballard, because we enact something important about it when we go to its coffee shops and restaurants, and because we are transients from other places. Furthermore, we are not always sure of our place in the city, or how our points of reference here may be changing. Much can be said about Seattle’s role in white settlement and in its original industries: shipping, canning, and logging. Much can be said about the arrival of Scandinavian laborers in Ballard, or how the town of Ballard came to be incorporated into Seattle. But as in maps, while these accounts may ground key details, they do not encompass our imaginations of place. Over the last few decades, new meanings in Ballard have been drawn from the built environment. An old railroad track, since converted into a bike path, allows close-up views of storage lots, dry docks and shipyards still lining the ferryway at Ballard’s south edge. Hardware stores and auto repair shops remain clustered along an early bridge and what used to be the city’s first major highway. Nearby, along Market Street and Ballard Avenue, a parallel world of leisure has sprung up celebrating craft processes of work. This is a world of artisan beer, gluten-free pizza, organic coffee, vintage clothing, designer furniture, and one of the city’s finest year-round farmer’s markets. In the past, a noodle shop, a tapas bar, and a Mexican food cart might all have been out of place, but today, they all hang in the balance. As a widening array of consumer spaces channels urban trajectories into the future, contemporary landscapes and lifestyles are retrofitted to traces of the past. The functional and aesthetic components of cities are affected by scales far outside the neighborhood. But as Ballard’s rapidly changing housing market attests, people resituate themselves and the places around them by winnowing out distances and connections between self and other. Condo owners, young couples, single adults, students, senior citizens, and the homeless scramble, revise and recompile landscapes in dynamic and uneven ways. Often, these shifts are an open secret in which past and future are sutured together — debated, digested, and dreamed over. (shrink)

Minkoff, Vullikanit, and Marshall (2024) have advanced critical dialogue about the agency of pregnant persons, highlighting serious issues about the erosion of reproductive rights and the fall of R...

Recent financial fraud legislation such as the Dodd–Frank Act and the Sarbanes–Oxley Act (U.S. House of Representatives, Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, [H.R. 4173], 2010 ; U.S. House of Representatives, The Sarbanes–Oxley Act of 2002, Public Law 107-204 [H.R. 3763], 2002 ) relies heavily on whistleblowers for enforcement, and offers protection and incentives for whistleblowers. However, little is known about many aspects of the whistleblowing decision, especially the effects of contextual and wrongdoing attributes on organizational (...) members’ willingness to report fraud. We extend the ethics literature by experimentally investigating how the nature of the wrongdoing and the awareness of those surrounding the whistleblower can influence whistleblowing. As predicted, we find that employees are less likely to report: (1) financial statement fraud than theft; (2) immaterial than material financial statement fraud; (3) when the wrongdoer is aware that the potential whistleblower has knowledge of the fraud; and (4) when others in addition to the wrongdoer are not aware of the fraud. Our findings extend whistleblowing research in several ways. For instance, prior research provides little evidence concerning the effects of fraud type, wrongdoer awareness, and others’ awareness on whistleblowing intentions. We also provide evidence that whistleblowing settings represent an exception to the well-accepted theory of diffusion of responsibility. Our participants are professionals who represent the likely pool of potential whistleblowers in organizations. (shrink)

The purpose of this article is to critique the primary arguments given by Paul Bloom and Jesse Prinz against empathy, and to argue instead that empathy is best understood as a virtue that plays an important but complicated role in the moral life. That it is a virtue does not mean that it always functions well, and empathy sometimes contributes to behavior that is partial and unfair. In some of their writings, both Bloom and Prinz endorse the view that (...) empathy is a fixed trait, but there is little reason to think this, and the studies that they cite do not support this view. Further, a number of recent studies suggest the opposite: our empathic reactions are malleable and subject to environmental effects and learning. Although our capacities for cognitive and emotional empathy are clearly not sufficient for being moral, I argue that they are functionally necessary traits that, like other virtues, must be cultivated correctly. (shrink)

Records of certain Government Departments known to have purchased scientific instruments from designated suppliers over long periods are potentially important sources of information on both instruments and their makers. The Office of Ordnance was one such Department. Investigation of its financial and administrative records has shown that the appointment ‘Mathematical Instrument Maker to his Majesty's Office of Ordnance’ brought the holder a substantial trade in instruments for drawing, surveying, and military purposes. Detailed entries in the Bill Books enable not only (...) types, quantities, and prices of instruments supplied to be determined, but also the purposes for which they were required. In many cases the actual users of the instruments are named, with their locations in Great Britain and overseas.The records of the Office of Ordnance are extensive, covering the mid-seventeenth to the mid-nineteenth century in over ten thousand volumes or bundles. This paper provides an introduction to what is available, and examines in particular the period 1748–1772 when George Adams senior was Mathematical Instrument Maker to this Office. It is shown that during this period Adams supplied over 1500 instruments, ranging from drawing pens to theodolites, detailed in 148 bills amounting to a total value of £2425. Some other well-known instrument makers, such as Thomas Wright, Benjamin Cole & Son, and Jesse Ramsden, were also occasional suppliers of instruments in the same period, while from 1765 onwards the records include bills for instruments purchased by the Office of Ordnance for the Royal Observatory from makers such as Dollond and Bird. The total number of instrument makers' bills located and examined in the period searched, including the 148 by Adams, was 166. In addition, though not within the scope of this paper it was observed that the records contain numerous bills by William Deane before, and by Jeremiah Sisson after, the period of Adams' appointment respectively. (shrink)

Moral sentimentalism has seen a tremendous rise in popularity in recent years within contemporary meta-ethical theory, since it promises to delineate the normative domain in a naturalistically unobjectionable manner. After showing that both Michael Slote and Jesse Prinz’s sentimentalist positions fall short of fulfilling this promise, this essay argues that contemporary sentimentalists are advised to take their clues from Adam Smith rather than David Hume. While Hume was absolutely right in emphasizing the importance of empathy in the moral context, (...) his official description of the mechanisms of empathy as articulated in the Treatise falls fundamentally short for this purpose. Adam Smith’s conception of empathy, a conception that in fact is closer to some of Hume’ remarks in the Enquiry rather than the Treatise, as essentially involving perspective taking and his appeal to the impartial spectator perspective proves to be more fertile. Only in this manner do sentimentalists have any hope of accounting for the intersubjective normative and obligatory dimension of moral judgments. (shrink)